https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:44824 Thu 27 Oct 2022 12:44:28 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45372 Chd4 expression significantly impairs SSC regenerative capacity, causing a ∼50% reduction in colonization of recipient testes. An scRNA-seq comparison revealed reduced expression of “self-renewal” genes following Chd4 knockdown, along with increased expression of signature progenitor genes. Co-immunoprecipitation analyses demonstrated that CHD4 regulates gene expression in spermatogonia not only through its traditional association with the remodeling complex NuRD, but also via interaction with the GDNF-responsive transcription factor SALL4. Cumulatively, the results of this study depict a previously unappreciated role for CHD4 in controlling fate decisions in the spermatogonial pool.]]> Thu 27 Oct 2022 12:14:10 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:55287 Fri 10 May 2024 16:22:11 AEST ]]>